BackgroundAlthough patient advocates have developed templates for standard consent forms, evaluating patient preferences for first in human (FIH) and window of opportunity (Window) trial consent forms is critical due to their unique risks. FIH trials are the initial use of a novel compound in study participants. In contrast, Window trials give an investigational agent over a fixed duration to treatment naïve patients in the time between diagnosis and standard of care (SOC) surgery. Our goal was to determine the patient-preferred presentation (...) of important information in consent forms for these trials.MethodsThe study consisted of two phases: (1) analyses of oncology FIH and Window consents; (2) interviews of trial participants. FIH consent forms were analyzed for the location(s) of information stating that the study drug has not been tested in humans (FIH information); Window consents were analyzed for the location(s) of information stating the trial may delay SOC surgery (delay information). Participants were asked about their preferred placement of the information in their own trial’s consent form. The location of information in the consent forms was compared to the participants’ suggestions for placement. Results34 [17 FIH; 17 Window] of 42(81%) cancer patients approached participated. 25 consents [20 FIH; 5 Window] were analyzed. 19/20 FIH consent forms included FIH information, and 4/5 Window consent forms included delay information. 19/20(95%) FIH consent forms contained FIH information in the risks section 12/17(71%) patients preferred the same. Fourteen (82%) patients wanted FIH information in the purpose, but only 5(25%) consents mentioned it there. 9/17(53%) Window patients preferred delay information to be located early in the consent, before the “Risks” section. 3/5(60%) consents did this.ConclusionsDesigning consents that reflect patient preferences more accurately is essential for ethical informed consent; however, a one-size fits all approach will not accurately capture patient preferences. We found that preferences differed for FIH and Window trial consents, though for both, patients preferred key risk information early in the consent. Next steps include determining if FIH and Window consent templates improve understanding. (shrink)

The extended mind view and the embodied-grounded view of cognition and language are typically considered as rather independent perspectives. In this paper we propose a possible integration of the two views and support it proposing the idea of “Words As social Tools” (WAT). In this respect, we will propose that words, also due to their social and public character, can be conceived as quasi-external devices that extend our cognition. Moreover, words function like tools in that they enlarge the bodily space (...) of action thus modifying our sense of body. To support our proposal, we review the relevant literature on tool-use and on words as tools and report recent evidence indicating that word use leads to an extension of space close to the body. In addition, we outline a model of the neural processes that may underpin bodily space extension via word use and may reflect possible effects on cognition of the use of words as external means. We also discuss how reconciling the two perspectives can help to overcome the limitations they encounter if considered independently. (shrink)

Affordances, i.e. the opportunity of actions offered by the environment, are one of the central research topics for the theoretical perspectives that view cognition as emerging from the interaction between the environment and the body. Being at the bridge between perception and action, affordances help to question a dichotomous view of perception and action. While Gibson’s view of affordances is mainly externalist, many contemporary approaches define affordances as the product of long-term visuomotor associations in the brain. These studies have emphasized (...) the fact that affordances are activated automatically, independently from the context and the previous intention to act: for example, affordances related to objects’ size would emerge even if the task does not require focusing on size. This emphasis on the automaticity of affordances has led to overlook their flexibility and contextual-dependency. In this contribution I will outline and discuss recent perspectives and evidence that reveal the flexibility and context-dependency of affordances, clarifying how they are modulated by the physical, cultural and social context. I will focus specifically on social affordances, i.e. on how perception of affordances might be influenced by the presence of multiple actors having different goals. (shrink)

Transient receptor potential vanilloid 4 (TRPV4), a member of the TRP superfamily, is a broadly expressed, cell surface‐localized cation channel that is activated by a variety of environmental stimuli. Importantly, TRPV4 has been increasingly implicated in the regulation of cellular morphology. Here we propose that TRPV4 and the cytoskeletal remodeling small GTPase RhoA together constitute an environmentally sensitive signaling complex that contributes to pathological cell cytoskeletal alterations during neurological injury and disease. Supporting this hypothesis is our recent work demonstrating direct (...) physical and bidirectional functional interactions of TRPV4 with RhoA, which can lead to activation of RhoA and reorganization of the actin cytoskeleton. Furthermore, a confluence of evidence implicates TRPV4 and/or RhoA in pathological responses triggered by a range of acute neurological insults ranging from stroke to traumatic injury. While initiated by a variety of insults, TRPV4–RhoA signaling may represent a common pathway that disrupts axonal regeneration and blood–brain barrier integrity. These insights also suggest that TRPV4 inhibition may represent a safe, feasible, and precise therapeutic strategy for limiting pathological TRPV4–RhoA activation in a range of neurological diseases. (shrink)

Following SOX, financial restatements increased dramatically. Prior research suggests that how investors respond to restatements, particularly those involving fraud, may mitigate or exacerbate damage suffered. We extend both accounting and management research by examining the joint effects of pre-restatement managerial reputation and the announcement of managerial corrective actions in response to a restatement on nonprofessional investors’ judgments. We find that pre-restatement managerial reputation and the announcement of managerial corrective actions jointly influence investors’ managerial fraud prevention assessments, which mediate their trust (...) in management. These trust perceptions in turn affect investors’ investment and CEO retention judgments. Our results have implications for firms that are concerned with lessening the negative consequences associated with issuing a restatement. (shrink)

Recent theories on abstract concepts and words (ACs), such as Words As social Tools (WAT) (Borghi et al., 2019b) and Language is an Embodied Neuroenhancement and Scaffold (LENS) (Dove, 2019) have underlined the crucial role of both sensorimotor experience and language for ACs representation and use [see Dove et al. (2020), for a comparison]. Here we focus on the WAT view. WAT highlights the role of language, sociality, and inner grounding (interoception, metacognition) for ACs. Furthermore, WAT seeks to integrate a (...) developmental perspective with approaches focusing on conceptual use and brain representation. We briefly illustrate evidence coming from both clinical and non-clinical populations and identify areas where additional evidence that ACs evoke linguistic, social, and interoceptive experience is still needed. (shrink)

The topic is characterized by a highly interdisciplinary approach to the issue of action and language integration. Such an approach, combining computational models and cognitive robotics experiments with neuroscience, psychology, philosophy, and linguistic approaches, can be a powerful means that can help researchers disentangle ambiguous issues, provide better and clearer definitions, and formulate clearer predictions on the links between action and language. In the introduction we briefly describe the papers and discuss the challenges they pose to future research. We identify (...) four important phenomena the papers address and discuss in light of empirical and computational evidence: (a) the role played not only by sensorimotor and emotional information but also of natural language in conceptual representation; (b) the contextual dependency and high flexibility of the interaction between action, concepts, and language; (c) the involvement of the mirror neuron system in action and language processing; (d) the way in which the integration between action and language can be addressed by developmental robotics and Human-Robot Interaction. (shrink)

Arbib suggests that language emerged in direct relation to manual gestural communication, that Broca's area participates in producing and imitating gestures, and that emotional facial expressions contributed to gesture-language coevolution. We discuss functional and structural evidence supporting localization of the neuronal modules controlling limb praxis, speech and language, and emotional communication. Current evidence supports completely independent limb praxis and speech/language systems.

Thinking about what the senses cannot grasp is one of the hallmarks of human cognition. We argue that “intangible abstracta” are represented differently from other products of abstraction, that goal-derived categorization supports their learning, and that they are grounded also in internalized linguistic and social interaction. We conclude by suggesting different ways in which abstractness contributes to cement group cohesion.

This volume explores how language, and particularly abstract language, shapes our thought. Academic researchers and graduate students in philosophy of language and cognitive sciences will benefit.

This paper examines the role of management's earnings preannouncements on judgments about its trustworthiness by nonprofessional investors. We predict that management's preannouncement decision and the resulting direction of the earnings surprise influence investors' ethical judgments about management's trustworthiness; these judgments, in turn, are associated with investors' other investment related judgments. We test our predictions in an experiment in which MBA students make investment-related judgments under four different preannouncement strategies. Consistent with our predictions, the results of our study show that managers' (...) preannouncement decisions are significantly associated with investors' evaluations of management's trustworthiness. Specifically, holding the size of the earnings surprise constant, we find that judgments of management's trustworthiness are damaged more following a negative as opposed to a positive earnings surprise, and the release of a preannouncement compared to when management does not issue a preannouncement. Also consistent with our predictions, we find that evaluations of management's trustworthiness are significantly and positively associated with judgments of the attractiveness of the firm's equity as an investment. Based on our findings, we encourage further research to explore whether managers understand the trust implications associated with their preannouncement decisions and the extent to which this understanding influences their disclosure decisions. (shrink)

This content analysis examines the ways that genocide is included in the high school world history content standards of eleven states with legislative mandates requiring genocide education, as well as if the content standards in those states differ from those of states without mandated genocide education. The null curriculum theorizes that the content that is not taught may be as important as what is taught; this lens allows for a nuanced analysis of the ways that genocide is included and excluded (...) in state standards. The findings suggest that states with legislative mandates requiring genocide education do not necessarily have high school world history content standards that require genocide education. The content standards in states with legislative mandates often omit acts of genocide, refrain from using the term “genocide,” and frame genocides as less important than the Holocaust, perpetuating the null curriculum of genocides. (shrink)

The article analyzes the little-known field of philosophical studies of M. Schlick, who was traditionally considered as a scientist dealing with the problems of epistemology and philosophy of science. In the spotlight of the research is the work On meaning of Life, where the philosopher not only lays the foundation for his future work on ethics but also offers an original approach to the problem of the meaning of life, linking it with the concept of "youth". He notes that most (...) people see the meaning of life in achieving certain goals. As a result, life is filled with activities aimed at preserving existence. The only way to find meaning in life is through an activity that has a purpose and value in itself, so the meaning of life cannot be found in work since it is not an activity for its own sake. The alternative is the game inherent in youth. It fills you with joy and gives value to life. The meaning of life symbolizes youth. You can be young at any time if you consider youth as a time of play, activity and creativity. It implies the requirement to change the conventional system of upbringing and conservative ethics. In particular, he insists that it is necessary to abandon the ethics of duty and replace it with new ethics, where the virtue is serene, does not suffer from the pressure of duty and freely unfolds of its own will. It is concluded that Schlick's ethics of youth is symptomatic of the first third of the twentieth century since those times were oriented to the new man, whose universal traits were health, cheerfulness, fortitude and social activism. (shrink)

This paper employs theory of normal organizational wrongdoing and investigates the joint effects of management tone and the slippery slope on financial reporting misbehavior. In Study 1, we investigate assumptions about the effects of sliding down the slippery slope and tone at the top on financial executives’ decisions to misreport earnings. Results of Study 1 indicate that executives are willing to engage in misreporting behavior when there is a positive tone set by the Chief Financial Officer, regardless of the presence (...) or absence of a slippery slope. A negative tone set by the CFO does not facilitate the transition from minor indiscretions to financial misreporting. In Study 2, we find that auditors evaluating executives’ decisions under the same conditions as those in Study 1 do not react to the slippery slope condition, but auditors assess higher risks of fraud when the CFO sets a negative tone. Overall, our results indicate that many assumptions about the slippery slope and tone at the top should be questioned. We provide evidence that pro-organizational behaviors and incrementalism yield new insights into the causes of ethical failures, financial misreporting behavior, and failures of corporate governance mechanisms. (shrink)

The notions of failure and denial are co-constitutive of both “global” theory and social order. Though these concepts have been used to evoke an array of metaphors and images to under­stand the condition of international relations as a knowledge production site and in rela­tion to other social sciences, they have not been deemed pivotal for much theorizing of world politics’ events, including the “success” of a sovereign state, or the subjects and knowledge production of decolonial realities. The article critically assesses (...) how the term failure is used by IR’s scholarly community as signifier and analogy and what it signifies and analogizes. It grapples with Bruno Latour’s “The Immense Cry Channeled” by Pope Francis and ‘“Love your Monsters.’” It concludes with a discussion of the ethics of critical theory and its empha­sis on critique. I problematize its critical moves to lodge racializations in the enslaved and colonized body and body politic of ‘failed’ states, and the normative projects it bolsters. I also point to its broader social and political implications, including its acknowledging of certain publics at the expense of others and its death limits in times of terror and the Anthropocene. I finally argue for a ‘global’ decolonizing social analysis that in an Fanonian sense, is a “real leap” as it introduces “invention into existence” by rupturing evolutionary trajectories and linear temporalities (i.e., pure immanence, or transcendentalism). (shrink)

A critical and aware return to pragmatism entails a preliminary focus upon the possibility of productive communication and a possible exchange among fields of research often far apart in terms of methods and spheres of application. This difficulty is felt all the more strongly if we refer to the contested intellectual legacy of George H. Mead, one often divided between opposing and conflicting fields of investigation. In this paper, I propose a reinterpretation of his thought that I believe could operate (...) transversally. To do so, I interpret Mead’s idea of human creativity in a more radical way compared with some previous interpretations. This way, it is possible to see the constructive role of the relation between inter-subjective and intra-subjective communication as constitutive moments in an ethical self-construction of human beings. Finally, the peculiarity of human creativity, in all its complexity, shows itself as the starting point for responsible, normatively oriented conduct. Moreover, a new anthropological paradigm, also emerging from Mead’s suggestions, could become a source of inspiration for a renewed pattern of civic life and democratic citizenship. (shrink)

Increasingly, feminist scholars examine how the stability of racial hierarchies is maintained through discourse. This article explores the importance of race discourse in the construction of white women's accounts explaining their race politics. Specifically, the author examines the connections between race discourse and politics as they emerged in interviews with white women involved in a local women's movement between 1972 and 1999. The interviews revealed five discursive strategies women used to talk about race and the movement's antiracist practices. In addition, (...) one of the most important contributions of this study is the evidence it provides of the relationship between the discursive construction of an “invisible white self” and the broader structure of power relations. (shrink)

That Catullus’ sixty-fourth poem influenced Virgil's work has long been accepted. We approach a little nearer a resolution of the enigma of the Fourth Eclogue when we recognize epithalamian elements within it that echo not only the song of the Parcae, but also the themes of the Golden Age, of the Voyage of the Argo, and of the relations between gods and men from Catullus’ poem. Similarly, Ariadne's part in the creation of Aeneid 4, both in the ‘marriage’ scene and (...) in Dido's reproaches to Aeneas, has been noted. (shrink)

The writer Anna M. Stoddart published biographies of Isabella Bird and the classical scholar John Stuart Blackie before this 1908 life of the educationalist Hannah E. Pipe. Pipe was sent in 1847 to Chorlton high school, run by William Ballantyne Hodgson, who mapped out for her a teaching career. This biography was written for, and at the urging of, Pipe's ex-pupils, concerned to record her life 'before it crumbles into oblivion'. She opened her first school in Manchester, but moved (...) to London in 1856: Stoddart herself was one of her staff; music was taught by Sterndale Bennett, and science by William Huggins. The school was enormously successful, and Pipe also became involved in other philanthropic causes, being a friend of Octavia Hill and F. D. Maurice. This is a fascinating account of an inspiring teacher and educational pioneer. (shrink)

Behavioral ethics research has focused predominantly on how the attributes of individuals influence their ethicality. Relatively neglected has been how macro-level factors such as the behavior of firms influence members’ ethicality. Researchers have noted specifically that we know little about how a firm’s CSR influences members’ behaviors. We seek to better merge these literatures and gain a deeper understanding of the role macro-level influences have on manager’s ethicality. Based on agency theory and social identity theory, we hypothesize that a company’s (...) commitment to CSR shifts managers’ focus away from self-interests toward the interests of the firm, bolstering resistance to temptation. We propose this occurs through self-categorization and collective identification processes. We conduct a 2 × 2 factorial experiment in which managers make expense decisions for a company with commitment to CSR either present or absent, and temptation either present or absent. Results indicate that under temptation, managers make decisions consistent with self-interest. More importantly, we find when commitment to CSR is present, managers are more likely to make ethical decisions in the presence of temptation. Overall, this research highlights the interactive role of two key contextual factors—temptation and firm CSR commitment—in influencing managers’ ethical decisions. While limited research has highlighted the positive effects that a firm’s CSR has on its employees’ attitudes, the current results demonstrate CSR’s effects on ethical behavior and imply that through conducting and communicating its CSR efforts internally, firms can in part limit the deleterious effects of temptation on managers’ decisions. (shrink)

Management has the opportunity to promote self-serving accounting practices, such as earnings management, when management can effectively avoid oversight by the audit committee. This article investigates the effects of financial knowledge and dispositional trust on the ability of audit committee members to recognize management attempts to avoid full disclosure to the board and potentially deceive board members. The results of a controlled laboratory experiment with 40 experienced audit committee member participants indicate that: Audit committee members with less financial knowledge are (...) more likely to accept insufficient client explanations for accounting judgments than are more knowledgeable audit committee members; Audit committee members with less financial knowledge are more likely to reject sufficient client explanations for accounting judgments than are more knowledgeable audit committee members; and Audit committee members that place higher levels of trust in others are more likely to accept insufficient client explanations for accounting judgments than are less trusting committee members. (shrink)

George H. Mead: A Therapy for the Malaise of Modernity? In his recent volume on Mead, Filipe Carreira da Silva proposes an interpretation of the pragmatist’s thought that develops through three fundamental points of reference. According to the author, science, selfhood and democratic politics constitute “the pillars” of a new approach to the problem of modernity; an approach in which the mutual interchange between these moments projects on the theoretical level a reflection of the relational...

Книгата е посветена на проблема за обосноваността от класическата интерналистка гледна точка на епистемологията. Тя преразглежда традиционните проблеми в интерналистката рамка в по-широкия контекст на развитието в тази област през последните петдесет години.Централните проблеми в изследването се отнасят до условията на обосноваността като резултат от епистемичната оценка на вярванията с помощта на свидетелства и основания. Сред тях са проблемът за характера на свидетелствата и мястото им в процедурата на епистемична оценка, проблемите за добрите и достатъчни основания и проблемът за регреса (...) на основанията. (shrink)

In “On Certainty” Wittgenstein regards doubting as meaningful and reasonable only in a context providing language game where some background is taken for granted. Doubt, just as knowledge, should be backed up by an argument, only this time, one presenting reasons for uncertainty. Common sense propositions constitute part of the background for the arguments of doubting and because of their function and place within the system of language, they are regarded as indubitable. I discuss critically the idea of linguistically determined (...) indubitability and advocate the possibility of a different kind of doubt, one that does not require its own justification and is still a reasonable epistemic attitude. Such doubt characterizes the states of affairs where the certainty of a proposition is not yet rationally established. I argue that, language does not limit us in doubting and in doubting reasonably. (shrink)

The article introduces theories of epistemic justification to the problems of understanding in communication. Two dominant approaches in contemporary epistemology — foundationalism and coherentism — are applied in intercultural discourse. Since the intended meaning of utterances in communication is reached through inference, beliefs about the intended meaning are justified with respect to the evidence of communicative behaviour and context. Tracing the difficulties of intercultural dialogue, the article argues that the coherentist method of justification is more useful than foundationalist one. Coherentism (...) is consistent with the open-mindedness and unprejudiced reasoning, both of which are crucial parts of intercultural competency. (shrink)

Two experiments, one on school-aged children and one on adults, explored the mechanisms underlying responses to an image prime followed by graspable objects that were, in certain cases, dangerous. Participants were presented with different primes and objects representing two risk levels . The task required that a natural/artifact categorization task be performed by pressing different keys. In both adults and children graspable objects activated a facilitating motor response, while dangerous objects evoked aversive affordances, generating an interference-effect. Both children and adults (...) were sensitive to the distinction between biological and non-biological hands, however detailed resonant mechanisms related to the hand-prime gender emerged only in adults. Implications for how the concept of “dangerous object” develops and the relationship between resonant mechanisms and perception of danger are discussed. (shrink)